People who got Sinovac vaccine nearly 5 times more likely to develop severe COVID-19 than Pfizer: Singapore study - CNA

THE STUDY

The study’s authors included NCID’s executive director Leo Yee Sin, chair of the expert committee on COVID-19 vaccination Benjamin Ong, MOH senior assistant director Wycliffe Wei, as well as MOH director of communicable diseases Vernon Lee.

The study aimed to compare the effectiveness of mRNA vaccines and inactivated whole virus vaccines in the same population. The findings will be useful for guiding policy recommendations to prevent infection and reduce strain on the healthcare system, the paper said.

Of the 2,709,899 individuals involved in the study, about 74 per cent received the Pfizer-BioNTech vaccine, 23 per cent took the Moderna vaccine, while 2 per cent received the Sinovac vaccine and 1 per cent the Sinopharm vaccine.

The Pfizer-BioNTech vaccine was approved for use under the programme in Singapore on Dec 30, 2020, while the Moderna and Sinovac vaccines were approved on Feb 3, 2021 and Oct 23, 2021 respectively.

From Aug 30, 2021, the Sinopharm vaccine was also available at private healthcare institutions, but not part of the national programme.

The cohort was restricted to those two weeks after completion of two vaccine doses to allow sufficient immune response, and who had received their second dose within 120 days of the analysis.

A total of 107,220 of those vaccinated were confirmed by polymerase chain reaction (PCR) tests to have COVID-19 over the study period, and 644 developed severe disease.

While the study was based on “comprehensive national data”, the team said there were “several limitations”.

This included the “residual confounding” from comorbidities as well as factors that influence a person’s choice of vaccine or risk of exposure. There were also asymptomatic cases who did not see a doctor and were not recorded as cases.

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2022-04-14 04:48:00Z
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